Quick Answer: Which Antidepressant Is Best For Chronic Pain?

Serotonin and norepinephrine reuptake inhibitors (SNRIs).

Some SNRIs , such as venlafaxine (Effexor XR), duloxetine (Cymbalta, Drizalma Sprinkle), milnacipran (Savella) and desvenlafaxine (Pristiq), may help relieve chronic pain.

People with chronic pain often develop depression along with their chronic pain.

What is the best antidepressant for pain?

The most efficacious antidepressants for the treatment of neuropathic pain appear to be the tertiary-amine TCAs (amitriptyline, doxepin, imipramine), venlafaxine, bupropion, and duloxetine.

Can antidepressants help with pain?

At doses lower than those needed to treat depression, antidepressants can relieve chronic pain in conditions ranging from diabetic neuropathy, migraine and tension headaches, to osteoarthritis and fibromyalgia. In fact, they are so effective, that antidepressants are the mainstay for treating chronic pain.

Can zoloft help with chronic pain?

Researchers reviewed 50 studies of 19 different antidepressants in the treatment of pain caused by nerve tissue damage, also known as neuropathic pain. They found that the older class of antidepressants called tricyclics can provide significant pain relief. SSRIs include Prozac, Celexa, Luvox, Zoloft, and Paxil.

What is the best antidepressant for fibromyalgia?

Duloxetine (Cymbalta), an antidepressant, is another drug approved by the FDA for the treatment of fibromyalgia. Cymbalta is an antidepressant that belongs to a class of drugs called serotonin and norepinephrine reuptake inhibitors (SNRIs).

Why do doctors prescribe antidepressants for pain?

Tricyclics have been around since the 1950s and are the most common antidepressants prescribed for pain. They affect two chemicals in your body — serotonin and norepinephrine. Both help regulate your mood. Selective serotonin reuptake inhibitors (SSRIs) only affect serotonin.

What pain medication can you take with antidepressants?

New research suggests that both acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Motrin) may make selective serotonin reuptake inhibitors, or SSRIs, less effective.

What antidepressant is used for chronic pain?

Some SNRIs , such as venlafaxine (Effexor XR), duloxetine (Cymbalta, Drizalma Sprinkle), milnacipran (Savella) and desvenlafaxine (Pristiq), may help relieve chronic pain. People with chronic pain often develop depression along with their chronic pain.

How does serotonin affect pain?

Says Dong: “Chronic pain seems to cause serotonin to be released by the brain into the spinal cord. There, it acts on the trigeminal nerve at large, making TRPV1 hyperactive throughout its branches, even causing some non-pain-sensing nerve cells to start responding to pain.

Does Wellbutrin help with chronic pain?

One randomized controlled trial found that bupropion (Wellbutrin), which affects dopamine and norepinephrine, was helpful at alleviating chronic nerve pain, but not chronic low back pain unrelated to nerve damage. This may be an option for patients suffering nerve pain and depression.